| Week | Day | Date | Visitors | At | Time (CST) |
| 1 | Sun | 7-Sep |
Houston | Miami | 12:00 P.M. |
| 2 | Sun | 14-Sep |
Houston | New Orleans |
12:00 P.M. |
| 3 | Sun | 21-Sep |
Kansas City | Houston | 12:00 P.M. |
| 4 | Sun | 28-Sep |
Jacksonville | Houston | 12:00 P.M. |
| 5 | Sun | 5-Oct |
Denver | Kansas City | 12:00 P.M. |
| 6 | Sun | 12-Oct |
Houston | Tennessee | 12:00 P.M. |
| 7 | Sun | 19-Oct |
N.Y. Jets | Houston | 3:05 P.M. |
| 8 | Sun | 26-Oct |
Houston | Indianapolis | 3:15 P.M. |
| 9 | Sun | 2-Nov |
Carolina | Houston | 12:00 P.M. |
| 10 | Sun | 9-Nov |
Houston | Cincinnati | 12:00 P.M. |
| 11 | Sun | 16-Nov |
Houston | Buffalo | 12:00 P.M. |
| 12 | Sun | 23-Nov |
New England | Houston | 12:00 P.M. |
| 13 | Sun | 30-Nov |
Atlanta | Houston | 12:00 P.M. |
| 14 | Sun | 7-Dec |
Houston | Jacksonville | 12:00 P.M. |
| 15 | Sun | 14-Dec |
Houston | Tampa Bay | 12:00 P.M. |
| 16 | Sun | 21-Dec |
Tennessee | Houston | 12:00 P.M. |
| 17 | Sun | 28-Dec |
Indianapolis | Houston | 12:00 P.M. |